Biodistribution of 99m technetium- labeled creatinine in healthy rats

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Biodistribution of 99m technetium- labeled creatinine in healthy rats.

The distribution of creatinine, one of the toxic guanidine compounds, in various tissues has not been studied in detail by using radiolabeled creatinine. Our objective was to investigate the biodistribution of creatinine labeled with 99m technetium (99mTc) by the stannous (II) chloride method in healthy male Wistar rats. Quality controls were carried out by radio thin layer chromatography, high...

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In this study Isoniazid (INH) as one of the first line drugs in treatment of Tuberculosis was investigated to be loaded in Solid Lipid Nanoparticles (SLNs) for reducing hepatotoxicity as well as prolonging drug release. High shear homogenization method was performed to prepare INH SLNs. To compare biodistribution of INH before and after loading in SLNs, INH was labeled by Technetium 99 (Tc99) a...

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Syntheses, Characterization and Biodistribution of Technetium- 99m-Labeled Tetradentate Schiff Base Complexes

Received 10/28/2002; revised 11/20/2002; accepted 12/20/2002. For correspondence or reprints contact: Wen-Tao Huang, Ph.D., Department of Radiological Technology, Yuanpei University of Science and Technology, 306 Yuanpei Sreet, Hsinchu 300, Taiwan, R.O.C. Tel: (886)3-5381183 ext. 8312, Fax: (886)3-5385353, E-mail: [email protected] A series of tetradentate Schiff base compounds were synt...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2007

ISSN: 1414-431X,0100-879X

DOI: 10.1590/s0100-879x2006005000111